Our Research

Structure of the BAR-1 antibody, specific to a-2,3-sialyllactose.

The immune system functions to control and eliminate infectious agents and certain cancers, and to restore physiological homeostasis and repair damage. Combatting infectious agents and cancer can be achieved by harnessing the immune response to respond to these threats via vaccination. However, whilst vaccination against many pathogens has been relatively straightforward, others have been more difficult, such as the human immunodeficiency virus type-1 (HIV-1). Similarly, effective cancer vaccine approaches remain to be realised. Once the host has resolved an infection, the immune system has to repair tissue damage and restore homeostasis. Understanding mechanisms by which dying and dead cells are removed from the host by phagocytes is central to maintaining tissue health and avoiding inflammation.

Our research projects therefore focus on: i) investigating B cell responses and novel approaches to vaccine design, and ii) interrogating the mechanisms underlying dying cell recognition and removal by phagocytes.

We are located in The Sir William School of Pathology, Medical Sciences Division, University of Oxford.

Selected Publications

Deimel, L. P., Moynié, M., Sun, G., Lewis, V., Turner, A., Buchanan, C. J., Burlap, S. A., Kobras, C. M., Strack, M., Struwe, W. B., Baldwin, A. J., Naismith, J., Davis, B. G. & Sattentau, Q. J. (2023). Haptenic adducts of β-lactam antibiotics elicit antibody responses with narrow clonality and specificity. BioRxiv, 2023.11.02.565155; doi: https://doi.org/10.1101/2023.11.02.565155

Drexhage, L. Z.*, Zhang, S.*, DuPont, M., Ragaller, F., Sjule, E., Caballero, J. C., Deimel, L., Robertson, H., Russell, R. A., Dushek, O., Sezgin, E., Karaji, N., & Sattentau, Q. J. (2023). Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis. BioRxiv, 2023.08.22.554267. https://doi.org/10.1101/2023.08.22.554267

Deimel, L. P., Xue, X., Khan, A., Moynie, L., Buchanan, C. J., Sun, G., McBride, R., Schuster, H., Gauthier, C., Saliba, R., Leonavicus, K., Minall, L., Bort, G., Russell, R. A., Sezgin, E., Paulson, J. C., Anthony, D. C., Baldwin, A. J., Naismith, J., … Sattentau, Q. J. (2023). Engineered display of ganglioside-sugars on protein elicits a clonally and structurally constrained B cell response. BioRxiv, 2023.06.03.543556. https://doi.org/10.1101/2023.06.03.543556

Martin G.M., Russell R.A., Mundsperger P., Harris S., Jovanoska L., Trajano L.F., Schiffner T., Fabian K., Tolazzi M., Scarlatti G., McFarlane L., Cheeseman H., Aldon Y., Schermer E.E., Breemen M., Sliepen K., Katinger D., Kunert R., Sanders R.W., Shattock R., Ward A.B. & Sattentau Q.J. (2023). Profound structural conservation of chemically cross-linked HIV-1 envelope glycoprotein experimental vaccine antigens. NPJ Vaccines. 8(1), 101. https://doi.org10.1038/s41541-023-00696-w.

del Moral-Sánchez, I., Russell, R. A., Schermer, E. E., Cottrell, C. A., Allen, J. D., Torrents de la Peña, A., LaBranche, C. C., Kumar, S., Crispin, M., Ward, A. B., Montefiori, D. C., Sattentau, Q. J., Sliepen, K., & Sanders, R. W. (2022). High thermostability improves neutralizing antibody responses induced by native-like HIV-1 envelope trimers. Npj Vaccines, 7(1), 27. https://doi.org/10.1038/s41541-022-00446-4

Deimel, L. P., Liu, X., Gilbert-Jaramillo, J., Liu, S., James, W. S., & Sattentau, Q. J. (2022). Intranasal SARS-CoV-2 spike-based immunisation adjuvanted with polyethyleneimine elicits mucosal and systemic humoral responses in mice. Journal of Immunological Methods, 511, 113380. https://doi.org/https://doi.org/10.1016/j.jim.2022.113380

Deimel, L. P., Xue, X., & Sattentau, Q. J. (2022). Glycans in HIV-1 vaccine design - engaging the shield. Trends in Microbiology. https://doi.org/10.1016/j.tim.2022.02.004

Buchanan, C. J., Gaunt, B., Harrison, P. J., Yang, Y., Liu, J., Khan, A., Giltrap, A. M., le Bas, A., Ward, P. N., Gupta, K., Dumoux, M., Tan, T. K., Schimaski, L., Daga, S., Picchiotti, N., Baldassarri, M., Benetti, E., Fallerini, C., Fava, F., … Davis, B. G. (2022). Pathogen-sugar interactions revealed by universal saturation transfer analysis. Science, 377(6604), eabm3125. https://doi.org/10.1126/science.abm3125